Vinca alkaloids primarily affect cells in which phase?

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Multiple Choice

Vinca alkaloids primarily affect cells in which phase?

Explanation:
Vinca alkaloids block mitotic spindle formation by binding tubulin and preventing microtubule polymerization. This stops cells as they attempt to complete cell division, so they arrest during mitosis. DNA synthesis (S phase) and the growth phases before and after mitosis (G1 and G2) aren’t directly dependent on spindle assembly, so these drugs preferentially affect cells in M phase. In practice, cells treated with vinca alkaloids accumulate as they try to progress through metaphase, reflecting their action during mitosis.

Vinca alkaloids block mitotic spindle formation by binding tubulin and preventing microtubule polymerization. This stops cells as they attempt to complete cell division, so they arrest during mitosis. DNA synthesis (S phase) and the growth phases before and after mitosis (G1 and G2) aren’t directly dependent on spindle assembly, so these drugs preferentially affect cells in M phase. In practice, cells treated with vinca alkaloids accumulate as they try to progress through metaphase, reflecting their action during mitosis.

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