Chemotherapy and Radiation Therapy Practice Test

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Taxanes are which type of mitotic inhibitor and what do they do?

Antimicrotubule agents that stabilize microtubules during late G2 and mitosis

Taxanes are antimicrotubule agents that stabilize microtubules. They bind to beta-tubulin in the microtubule and prevent normal depolymerization, which is needed for the mitotic spindle to function during late G2 and mitosis. This locks the spindle in a rigid, polymerized state, so cells cannot progress from metaphase to anaphase, causing mitotic arrest and ultimately cell death. This mechanism is different from drugs that inhibit DNA synthesis or topoisomerases, which target DNA rather than the microtubule system.

Inhibit DNA polymerase

Bind to RNA

Inhibit topoisomerase

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