Hand-foot syndrome is most commonly associated with which drug?

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Multiple Choice

Hand-foot syndrome is most commonly associated with which drug?

Explanation:
Hand-foot syndrome (palmar-plantar erythrodysesthesia) is most closely linked to capecitabine because it is an oral prodrug of 5-fluorouracil that delivers continuous systemic exposure to the active metabolite. This leads to painful redness, swelling, and sometimes peeling on the palms and soles, a toxicity seen with capecitabine more than with many other chemotherapy agents. Other drugs on the list have different predominant toxicities—cisplatin is known for nephrotoxicity and ototoxicity, paclitaxel for neuropathy and myelosuppression, and doxorubicin for mucositis and cardiotoxicity—so hand-foot syndrome is least characteristic of them.

Hand-foot syndrome (palmar-plantar erythrodysesthesia) is most closely linked to capecitabine because it is an oral prodrug of 5-fluorouracil that delivers continuous systemic exposure to the active metabolite. This leads to painful redness, swelling, and sometimes peeling on the palms and soles, a toxicity seen with capecitabine more than with many other chemotherapy agents. Other drugs on the list have different predominant toxicities—cisplatin is known for nephrotoxicity and ototoxicity, paclitaxel for neuropathy and myelosuppression, and doxorubicin for mucositis and cardiotoxicity—so hand-foot syndrome is least characteristic of them.

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